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Diffuse Hair Loss In Women

The most common type of hair loss in women occurs in a diffuse pattern. Diffuse hair loss is most often hereditary, but it can also be caused by underlying medical conditions, medications, and other factors.

Common or “hereditary” hair loss in women, also called female pattern alopecia, is genetic and can come either the mother’s or father’s side of the family. It is caused by the actions of two enzymes; aromatase (which is found predominantly in women) and 5-a reductase (which is found in both women and men).

The action of 5-a reductase is the main cause of androgenetic alopecia in men, as this enzyme converts the hormone testosterone to DHT. DHT is responsible for the miniaturization (shrinking) and gradual disappearance of affected hair follicles.

One of the reasons hair loss in women happens is because women have half the amount of 5-a reductase compared to men, but have higher levels of the enzyme aromatase, especially at their frontal hairline. Aromatase is responsible for the formation of the female hormones estrone and estradiol. It also decreases the formation of DHT. Its presence in women may help to explain why the presentation of female hair loss is so different than in males, particularly with respect to the preservation of the frontal hairline. It may also explain why women have a poor response to the drug finasteride (Propecia), a medication widely used to treat hair loss in men that works by blocking the formation of DHT.

Women’s hair seems to be particularly sensitive to underlying medical conditions. Since “systemic” problems often cause a diffuse type of hair loss in women pattern,  this can be confused with genetic balding, it is important that women with undiagnosed hair loss, be properly evaluated. Medical conditions that produce a diffuse pattern include:

Medical conditions that can cause diffuse hair loss in women:
Obstetric and gynecologic conditions such as post-partum and post-menopausal states or ovarian tumors
Anemia – iron deficiency
Thyroid disease
Connective tissue diseases such as Lupus
Nutritional – crash diets, bulimia, protein/calorie deficiency, essential fatty acid or zinc deficiency, malabsorbtion, hypervitaminosis A
Stress – surgical procedures, general anesthesia, and severe emotional problems
A relatively large number of drugs can cause “telogen effluvium,” a condition where hair is shifted into a resting stage and then several months later shed. Fortunately, this shedding is reversible if the medication is stopped, but the reaction can be confused with genetic female hair loss if not properly diagnosed. Chemotherapy causes a diffuse type of hair loss called “anagen effluvium” that can be very extensive, but often reversible when the medication is stopped.
Drugs that can cause diffuse hair loss in women:

1. Blood thinners (anti-coagulants), such as warfarin and heparin
2. Seizure medication, most commonly dilantin
3. Medication for gout, colchicines and alopurinol (Xyloprim)
4. Blood pressure medication, particularly the b-blockers (such as Inderal) or diuretics
5. Anti-inflammatory drugs such as prednisone
6. Medications that lower cholesterol and other lipids
7. Mood altering drugs – lithium, tri-cyclics, Elavil, Prozac
8. Chemotherapy
9. Thyroid medications
10. Oral contraceptive agents, particularly those high in progestins
11. Misc. – diet pills, high doses of Vitamin A, street drugs (cocaine)
Localized Hair Loss

Although there are a host of dermatologic conditions that cause hair loss in women, they produce a pattern that is different from the diffuse pattern of genetic hair loss commonly seen in women and are easily differentiated from it by a dermatologist.

Localized hair loss in women may be sub-divided into scarring and non-scarring types. Alopecia Areata is a genetic, auto-immune disease that typifies the non-scarring type. It manifests with the sudden onset of discrete round patches of hair loss associated with normal skin. It can be treated with local injections of steroids.

Scarring Alopecia can be caused by a variety of medical or dermatologic conditions such as Lupus, Lichen Planus, or local radiation therapy. Hair loss from injuries, or from local medical problems that have been cured, are usually amenable to hair transplantation. Radiotherapy can cause both scarring and non-scarring localized hair loss and it also can be treated with surgical hair restoration if the area is not too large.

Localized hair loss in women that occurs around the hairline after face-lift surgery may be permanent. Traction Alopecia, the hair loss that occurs with constant tugging on the follicles, can also be permanent if the habit persists for a long period of time. Both of these conditions can be treated with hair transplantation.

Women with this type of hair loss have a pattern similar to what we observe in men. In other words, they have thinning in front or on top of their scalp with preservation of the hair in the permanent zone around the back and sides of the scalp. Thus, the balding is in a characteristic “pattern” rather than generalized.

Classification of Hair Loss in Women

As discussed in the section on the causes of hair loss in women, women’s hair loss can be classified into diffuse hair loss, localized hair loss, or patterned hair loss. It can also be divided into scarring and non-scarring types. Since the diffuse, non-scarring female hair loss caused by hereditary is so common, it has its own special classification that is based upon the degree of thinning called the Ludwig classification.

The Ludwig Classification uses three stages to describe female pattern genetic hair loss:

– Type I (mild)
– Type II (moderate)
– Type III (extensive)

In all three Ludwig stages, there is hair loss on the front and top of the scalp with relative preservation of the frontal hairline. The back and sides may or may not be involved. Regardless of the extent of hair loss, only women with stable hair on the back and sides of the scalp are candidates for hair transplant surgery.

Type I

Early thinning that can be easily camouflaged with proper grooming. Type I patients have too little hair loss to consider surgical hair restoration.

Type II

Significant widening of the midline part and noticeably decreased volume. Hair transplantation may be indicated if the donor area in the back and sides of the scalp is stable.

Type III

A thin, see-through look on the top of the scalp. This is often associated with generalized thinning.

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It is important for all women experiencing hair loss that an accurate diagnosis is made. This is particularly true when the hair loss is diffuse, as underlying medical conditions may be a contributing factor. Please refer to the diagnosis of hair loss in women page to learn about how the various types of female hair loss are evaluated.


The diagnosis of “female pattern” hair loss is relatively straightforward when there is a history of gradually thinning in the front and/or top of the scalp, relative preservation of the frontal hairline, a positive family history of hair loss, and the presence of miniaturization in the thinning areas.

Miniaturization is the progressive decrease of the hair shaft’s diameter and length in response to hormones. It can be observed using a densitometer, a hand-held instrument that magnifies a small area of the scalp where the hair has been clipped to about 1mm in length. With this instrument miniaturization is easily apparent.

UK Hair Transplant Clinics - hair loss in women Miniaturization
Normally follicular units (natural hair groups) are made of predominately of full-thickness, healthy terminal hair. With miniaturization one or more hairs within each group begin to thin. Eventually these hairs are lost.

If the hair loss is diffuse (thin all over) rather than in the typical female pattern on the front and top, the diagnosis can be more difficult. The presence of miniaturization in the areas of thinning usually confirms the diagnosis of androgenetic alopecia, however, if the diagnosis is still unclear, a number of other conditions must be ruled out. These have been listed in the section on Causes of Women’s Hair Loss.

Besides densitometry, two other common diagnostic tests that can be performed in the physician’s office are the hair-pull and hair pluck. In the hair pull, the physician grabs on to 20-30 hairs with his fingers and gently pulls on them. If five or more come out in the pull then this is suggestive of the increased shedding associated with telogen effluvium, a reversible type of female hair loss seen with stress, pregnancy, drug reactions and a variety of other conditions. Telogen effluvium generally occurs 2-3 months after a stressful event and affects 35-50% of one’s hair. Over 300 club hairs (telogen hairs that have rounded ends) can be shed per day shed.

In the hair pluck, 20 to 30 hairs are forcibly plucked from the scalp with a small clamp. The hair bulbs are then examined under a microscope to determine the ratio of anagen (growing) hairs to telogen (resting) hairs. Normally, at least 80% of the follicles should be in the anagen stage. A lower ratio would suggest telogen effluvium. With the hair pluck, various abnormalities of the hair shaft may be observed that can contribute to hair breakage and poor growth.

Anagen effluvium occurs when hair is shed in its growing phase and is characterized by large numbers of tapered or broken hairs (>80%). It can be caused by chemotherapy or radiation and can result in extensive hair loss in women.

Chronic Telogen Effluvium is a condition whose diagnosis is often missed, so it is worth mentioning briefly. Chronic TE affects women age 30-60. It starts abruptly with or without an initiating factor. Chronic TE presents with diffuse thinning with accentuation at the temples – often more apparent to the patient than to others. It has a long fluctuating course and patients can lose up to 50-400 hairs/day. There is increased shedding of telogen (club) hairs with a positive hair pull. Fortunately, the condition does not lead to complete baldness. Chronic TE can be expected to resolve spontaneously in 6 months to 6-7 years.

When the cause of the hair loss is still uncertain, further diagnostic information can be obtained from a scraping and culture for fungus and a scalp biopsy (sent for regular and special tissue stains and examined under both horizontal and vertical sections). A dermatologic consultation is warranted whenever the cause of hair loss is unclear.

Laboratory Evaluation for Androgen Excess

Occasionally, when a woman presents with female pattern hair loss, increased androgen production may be a contributing factor. The following signs and symptoms suggest that specific blood tests might be appropriate to rule out underlying sources of excess androgen:

  1. Irregular periods – for an extended period of time
  2. Cystic acne – severe acne which usually leaves scars
  3. Hirsuitism – increased body hair that doesn’t normally run in your family
  4. Virilization – appearance of secondary male sex characteristics such as a deepened voice
  5. Infertility – inability to become pregnant
  6. Galactorrahea – breast secretions when not pregnant (this is due to prolactin which is not actually an androgen)

It is important that when any of these symptoms are present, or these conditions are being considered, that you are under the care of a physician, to receive a proper evaluations and correct treatment if needed. Generally a gynecologist is the specialist most helpful for these problems.

Some of the tests that your doctor might order when considering androgen excess include:

  • Total and Free Testosterone – the hormone that is mainly responsible for male secondary sex characteristics
  • DHEA-Sulfate – a precursor to testosterone
  • Prolactin – the hormone that enables the breast to secrete milk

Localised Hair Loss

Localized hair loss in women is distinct from the diffuse thinning seen in female pattern alopecia. The following are the more common causes of local alopecia. A dermatologist should be consulted if any of these conditions are suspected. Note: the term alopecia is synonymous with hair loss).

Alopecia areata is recognized by the sudden appearance of discrete, round patches that are completely devoid of hair. Occasionally, the entire scalp may be involved (alopecia totalis) and even the entire body hair including the eyebrows and eyelashes (alopecia universalis). When localized, the lesions respond well to injections of cortisone. Generalized alopecia is more difficult to treat. The prognosis is better the older the age of onset. Alopecia areata can occasionally be associated with other conditions such as thyroid disease.

Hairstyles that exert constant pull on the hair, such as “corn rows” or tightly woven braids produce a characteristic pattern called “Traction Alopecia” that can be identified by a rim of thinning or baldness along the frontal hairline and at the temples. This is easily prevented by changing one’s daily hair-care habits, but once the hair loss occurs, it may be permanent. Fortunately, this condition is easily amenable to surgery if the cause can be eliminated.

Trichotillomania is a condition seen more commonly in young females, where the person twists, tugs or pulls out her hair. This can be scalp hair, eyebrows or eyelashes. The diagnosis is made by observing short, broken hairs in the area of hair loss. The patient may deny having this habit.

Face-lift and brow-lift procedures can result in local hair loss in the vicinity of the incision. This may present as hair loss along the frontal hairline, in the temples, or adjacent to a surgical scar. If female patients do not have genetic hair loss, and have a good donor supply, they may make excellent candidates for a hair transplant.

Tinea Capitis is a fungal infection of the scalp. It presents as irregular, red and scaly patches and/or small bald patches with broken hairs. The diagnosis is made by scraping a small piece of scale from the scalp and obtaining a bit of hair for testing. The specimens are sent for special fungal stains and cultures.

Pseudopalade is a non-specific scarring alopecia that generally starts on the top of the scalp and extends into the surrounding hair bearing areas with finger-like extensions. The areas look smooth and white due to the scarring and loss of hair follicles.

Lichen Plano-pilaris is an inflammatory condition of the scalp that presents with redness, scale and localized areas of hair loss. There is a characteristic scaling at the edge of each balding patch.

Discoid Lupus Erythematosus (DLE) is the localized form of Systemic Lupus Erythematosus (SLE), a potentially serious autoimmune disease. The localized form presents with red, scaly, pigmented patches of scarred skin. The localized form of the disease is mostly a cosmetic problem, but patients must be evaluated for the systemic disease as well with specific blood tests such as an ANA. SLE can cause diffuse (generalized) hair loss and both the local and systemic forms of the disease may cause sensitivity to the sun.

For more information about Female Hair Loss in the UK, Click here.

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